Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Assessment of the antidiabetic potential of Pterocarpus santalinoides extract in alloxan-induced diabetic rats

Kelechi G Madubuike¹ , Aruh O Anaga², Isaac U Asuzu²

¹Department of Veterinary Physiology and Pharmacology, Michael Okpara University of Agriculture, Umudike; ²Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria.

For correspondence:- Kelechi Madubuike Email: drkaycee2002@yahoo.com Tel:+2348036689778

Accepted: 22 October 2020 Published: 30 November 2020

Citation: Madubuike KG, Anaga AO, Asuzu IU. Assessment of the antidiabetic potential of Pterocarpus santalinoides extract in alloxan-induced diabetic rats. Trop J Pharm Res 2020; 19(11):2401-2406 doi: 10.4314/tjpr.v19i11.22

© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To establish the pharmacological basis for the antidiabetic use of Pterocarpus santalinoides.

Methods: Alloxan-induced diabetic rats were given graded doses (50, 100 and 200 mg/kg) of P. santalinoides extract (PSE) for 21 days. The fasting blood glucose (FBG), body weight, in vivo antioxidant assay, and lipid profile were determined.

Results: Pterocarpus santalinoides extract at all doses tested caused significant (p < 0.05) reduction in FBG and significant (p < 0.05) increase in body weight of treated rats when compared with the control. There were significant (p < 0.05) increases in the activities of antioxidant enzymes and high-density lipoprotein, while the levels of total cholesterol, triglycerides and low-density lipoprotein were significantly (p < 0.05) reduced in PSE-treated rats.

Conclusion: These results demonstrate the significant antidiabetic activity of P. santalinoides extract in albino Wistar rats, thus suggesting its potential application for the management of diabetes in humans, Furthermore, the findings may explain its use in ethnomedicine as an antidiabetic regimen.

Keywords: Pterocarpus santalinoides, Diabetes, Lipoprotein, Antioxidant, Hypoglycemia